TNF and breast cancer: On this trail, through a genome-wide analysis, Rajarajan et al. identified 98 miRNAs as differentially expressed in BC cells after co-culture with mature adipocytes compared to BC cells alone, together with a greater release of proinflammatory cytokines and chemokines by adipocytes, as IL1β, IL6, IL12, TNF-α and interferon-gamma (IFN-γ).