Through co-culture systems between 3T3-L1 adipocytes and BC cells, they reported that the switch to the CAA phenotype was associated with a dysregulation of genes involved in inflammatory pathways such as IL6 and Ptx3 upregulation, together with a pro-proliferative effect of Estrogen Receptor (ER) positive cell lines MCF7 and ZR-75-1. This evidence concerns the gene IL6 and breast cancer.