Therefore, if dental dysplasia in Parp-1−/− incisors could be a model of odontogenesis imperfecta, dentinogenesis imperfect, or dental dysplsia, the analysis of PARP-1 aberration would be a big key in looking for insights into not only these inherited autosomal dominant diseases, but also treatment of root canal. The gene discussed is PARP1; the disease is autosomal dominant disease.