A further dissection of these pathways has been performed by Li et al., demonstrating that cells from MM patients are enriched in long non coding (lnc) RNA against Runx2 pre-mRNA (lncRUNX2-AS1) which is shuttled through MM derived sEVs and transferred to MSCs, eventually decreasing osteogenesis [97]. Here, RUNX2 is linked to Miyoshi myopathy.