These findings were confirmed by the observation of the association of the MAT1A/MAT2A switch and low SAM levels, with CpG hypermethylation and histone H4 deacetylation of the Mat1A promoter, and CpG hypomethylation and histone H4 acetylation of Mat2A promoter in fast growing HCC of F344 rats [94]. The gene discussed is MAT1A; the disease is hepatocellular carcinoma.