Thus, on the basis of these observations, it may be concluded that a cooperation of SKP2 with N-Ras and AKT oncogenes promotes liver cancer in mice, in agreement with the observation that the nuclear translocation of SKP2 is associated, in human HCC, with activation of the AKT/mTOR and Ras/MAPK pathways. The gene discussed is AKT1; the disease is hepatocellular carcinoma.