A comparative study of human HCC with better prognosis (HCCB) and poorer prognosis (HCCP) revealed as higher up-regulation of HSP90/CDC37 and formation of protective complexes of p16INK4 and nuclear export of E2F4 by CRM1 in HCCP than in HCCB [124]. Here, CDKN2A is linked to hepatocellular carcinoma.