MAT1A and hepatocellular carcinoma: This was definitively and more directly demonstrated by the observation that MAT1A knockout mice, characterized by chronic SAM deficiency, exhibit hepatomegaly at 3 months of age, extended macrovesicular steatosis of hepatocytes and mononuclear cell infiltration in periportal areas at 8 months of age and, ultimately, leading to HCC development by 18 months of age [95].