Further, a decrease in AUF1 protein and MAT1A-AUF1 ribonucleoprotein, and a rise in HuR protein and MAT2A-HuR ribonucleoprotein, with a consequent destabilization of MAT1A and increased stability of MAT2B, occur in human HCC [99]. Here, MAT1A is linked to hepatocellular carcinoma.