DUSP1 and hepatocellular carcinoma: Furthermore, DUSP1 expression is related to HCC prognosis, being higher in HCCB than in HCCP, in which DUSP1 promoter hypermethylation, loss of heterozygosity at the DUSP1 locus, and phosphorylation, followed by ubiquitination and proteasomal degradation of DUSP1 protein, occurs [128].