SKP2 and hepatocellular carcinoma: These findings suggest a putative prognostic role of pERK1/2 and DUSP1 and the possibility that pERK1/2 and SKP2–CKS1 ligase cooperate [67], through DUSP1 phosphorylation and FOXM1 activation, to provide a positive feedback regulation of HCC proliferation [129] (Figure 3).