It was observed that the forced overexpression of Skp2, N-RasV12, or ΔN90-β-catenin, alone or the co-expression of Skp2 and ΔN90-β-catenin did not induce liver tumor development, while overexpression of myr-Akt1 alone induced HCC development after long latency [70]. This evidence concerns the gene SKP2 and hepatocellular carcinoma.