Double knockout NRF-2/PGC-1α mice develop dry AMD-like phenotype on the background of significant age-dependent RPE degeneration, accumulation of the oxidative stress markers, increased levels of protein aggregation markers (ubiquitin and p62) and the increased size of autolysosomes in RPE cells, indicating an insufficient rate in autophagic and proteasomal clearance [36]. This evidence concerns the gene SQSTM1 and dry age related macular degeneration.