The Sepsis Coagulopathy Asahi Recombinant LE Thrombomodulin (SCARLET) randomized clinical trial, an expanded phase III clinical trial of the phase IIb study, also failed to show the improvement of thrombomodulin in the 28-day all-cause mortality in the treatment of sepsis-associated DIC [12]. The gene discussed is THBD; the disease is Sepsis.