In addition, drivers of melanoma invasion and metastasis, such as ∆Ex2/3p73 (named DNp73), a transactivation-deficient N-terminally truncated oncogenic isoform of the TP73 gene, can trigger an IGF1R-AKT/STAT3 signaling cascade, which leads to the activation of EMT markers and acquisition of mesenchymal cell phenotypes [43,44]. This evidence concerns the gene STAT3 and melanoma.