In accordance with the results described above, Sathe et al. reported that an IL-15/JAK1/STAT5 pathway supports the generation of NK cells via transactivation of the antiapoptotic protein MCL1, and that MCL1 conditional knockdown in NK cells in mice led to multiorgan metastases upon transplantation of melanoma tumors [64]. The gene discussed is STAT5A; the disease is melanoma.