Our results indicated that PCW reduces FFA-induced phosphorylation of mTOR and p70S6K concomitantly increases AMPK phosphorylation; however, treatment with compound C significantly blocks these effects, suggesting that PCW activates autophagy by inhibiting mTOR via AMPK, which may also contribute to attenuate hepatic steatosis. Here, RPS6KB1 is linked to Hepatic steatosis.