Inhibitory effects of 18 towards SUV39H1 were found to provoke endoplasmic reticulum (ER) stress and results in the upregulation of the activating transcription factor 3 (ATF3) and C/EBP homologous protein (CHOP) in non-small cell lung cancers, suggestive of DR5-dependent apoptosis [104]. This evidence concerns the gene DDIT3 and non-small cell lung carcinoma.