Verticillin A (13) sensitized metastatic human colon carcinoma cells to Fas-mediated apoptosis, exhibiting greater efficacy than decitabine and vorinostat, increasing also death receptor 5 (DR5) expression to effectively overcome resistance to DR5 agonist drozitumab-induced apoptosis [83]. Here, TNFRSF10B is linked to colon carcinoma.