SUV39H1 and colon carcinoma: However, verticillin A (13) was brought into the spotlight due to the ability to suppress human colon carcinoma cells immune escape and to overcome 5-fluorouracil (5-FU) chemoresistance, which was associated with a selective inhibition of the HMTases SUV39H1, SUV39H2, and G9a/GLP that exhibit redundant functions in H3K9 trimethylation and FAS transcriptional silencing [83].