Following treatment with 11,11’-dideoxyverticillin (14), the secretion of VEGF from human MDA-MB-468 breast carcinoma cells was lowered, significantly suppressing VEGF-induced tyrosine phosphorylation of the endothelial cell-specific receptors Flt-1 and KDR/Flk-1 [90]. The gene discussed is KDR; the disease is breast carcinoma.