Apart from cancer, allelic losses or gains involving FADD have been associated with developmental disabilities or congenital anomalies (specifically, global developmental delay for ClinVar Variation ID 153941; global developmental delay and abnormal heart morphology for ClinVar Variation ID 442080; abnormality of the ear, obsolete malformation of the heart and great vessels, short stature and polydactyly for ClinVar Variation ID 441904; and micrognathia, syndactyly, intrauterine growth retardation, ventricular septal defect and abnormal facial shape for ClinVar Variation ID 441903) [48]. The gene discussed is FADD; the disease is Global developmental delay.