In this review, we illustrate the incidence, the role in tumorigenesis and the clinical implications of PTEN deregulation in ovarian cancer (OC), endometrial cancer (EC), cervical cancer (CC), vulvar cancer (VC) and uterine cancer (UC), including mainly uterine carcinosarcoma/uterine malignant mixed mullerian tumour and leiomyosarcoma. This evidence concerns the gene PTEN and uterine cancer.