Finally, an integrated genome analysis was performed on 84 uterine leiomyosarcoma samples (60 new samples and 24 from TGCA) by the same group, revealing a significantly higher rate of PTEN alterations (75% of samples), mainly due to gene deletions (71%) resulting in downregulation in 58% of cases [79]. Here, PTEN is linked to leiomyosarcoma.