PTEN and cancer: Considering the incidence of PTEN alterations (including all somatic chromosomal abnormalities and gene mutations) across human cancers, the highest percentages are found in endometrium, central nervous system (glioblastoma), skin, and prostate cancers according to the Catalogue of Somatic Mutations in Cancer (COSMIC) and The Cancer Genome Atlas Network (TGCA) datasets [8,9].