Controversially, a previous study using a genetically-defined pancreatic cancer cell panel, which was used to test their responses to chemotherapeutic drugs, found that SMAD4-inactivated cancer cell lines are more sensitive to cisplatin and irinotecan, but modestly (not statically significant) less sensitive to gemcitabine [36]. Here, SMAD4 is linked to familial pancreatic carcinoma.