Although, TGFβ-induced EMT is considered a pro-tumorigenic effect, it becomes lethal in TGFβ-sensitive (SMAD4-wildtype) pancreatic cancer by converting TGFβ-induced Sox4 from an enforcer of tumorigenesis into a promoter of apoptosis [40]. Here, TGFB1 is linked to familial pancreatic carcinoma.