Of note, the diagnosis of patients with LDS prompting molecular testing is not always straightforward, since the spectrum of clinical manifestations is broad and often overlaps other HCTDs, including Marfan syndrome (MFS), Shprintzen-Goldberg syndrome, some types of cutis laxa, Ehlers-Danlos syndromes (EDS) (particularly the vascular type), arterial tortuosity syndrome, congenital contractual arachnodactyly, and biglycan (BGN)-associated aortic aneurysm syndrome. This evidence concerns the gene BGN and Marfan syndrome.