FBXW7 and neoplasm: It is clear that FBXW7 (F-box and WD repeat domain-containing 7) plays the role of tumor suppressor, being involved in ubiquitination and degradation of several oncoproteins, such as c-Myc, Cyclin E, Notch, SREBP (sterol regulatory element-binding protein), Mcl1 and many others [13,14,15,16].