Among these, the upregulation of WD Repeat and SOCS box-containing 1 (WSB1), F-box and leucine-rich repeat protein 12 (FBXL12) and Ras-like without CAAX 1 (RIT1, also known as RBX1) genes [11] seems to be a remarkable evidence, since F-box proteins and SCF ligases, received gaining attention as molecular targets in several malignancies, including CRC [12]. This evidence concerns the gene FBXL12 and colorectal carcinoma.