In contrast, anti-arrhythmogenic effect was observed after mtCU activation in catecholaminergic polymorphic ventricular tachycardia (CPVT), a disease associated with mutation in RYR2 and characterized by episodes of life-threatening ventricular tachycardia upon the catecholaminergic stimulation after physical exercise or emotional stress [110]. The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.