NR1I2 and cancer: PXR was at first reported to be an important regulator of the metabolism of endogenous substances, drugs, and xenobiotics [9], but subsequent research reported a much wider array of functions in crucial physiological processes such as bile acid detoxification and elimination, glucose and lipid homeostasis, cholesterol metabolism, inflammation, bone metabolism, bilirubin clearance, oxidative stress, and cancer [10,11,12,13,14,15,16,17].