With respect to the top 5 downregulated candidate lncRNAs, lncRNA DIO3OS (P < .001), LncRNA MEG3 (P = .002), and lncRNA RP5‐983L19.2 (P < .001) were downregulated in AML patients compared with controls, while the expressions of lncRNA ST3GAL6‐AS1 (P = .080) and lncRNA OR51A10P (P = .227) were similar between AML patients and controls (Figure 6B). Here, DIO3OS is linked to acute myeloid leukemia.