GPER1 has been implicated in cell proliferation in various other tumors, and its ligand was recently demonstrated to be efficacious for treatment of melanoma in mice models.38 Genistein activates GPER1 with an EC50 of 133 nmol/L.39 We note that GPER1 agonists (G1, genistein, AXP107‐11) were more efficacious in MiaPaCa2 than in PANC1 in our study, although GPER1 was expressed at higher levels in PANC1. This evidence concerns the gene GPER1 and melanoma.