ESR1 and familial pancreatic carcinoma: GPER1 is a trans‐membrane G protein‐coupled receptor that was cloned in 1997,33 but not established as an membrane‐bound estrogen receptor until 2005.34 Studies of Gper1 knockout mice has indicated that GPER1 has a metabolic role in the in vivo pancreas,35 but it has previously not been linked to pancreatic cancer.