A model illustrating the generated mechanism of action in pancreatic cancer is illustrated in Figure 4D. This suggested that genistein activates GPER1, which in turn impacts MAPK signaling with subsequent activation of downstream transcription factors (including VDR, RXRA, SP1, DDIT3) and apoptotic signaling (including CASP9). This evidence concerns the gene DDIT3 and familial pancreatic carcinoma.