PROM1 and neoplasm: Today, the gold standard for the determination of GSCs remains the capability of these cells to reshape the complexity of the initial patient tumor after serial orthotopic transplantation assays into mice brains.8 Many studies have explored known normal stem cell markers such as CD133 or CD44 to recognize and enrich GSC cultures with flawed results as other cells that do not express such markers also display tumorigenic capacities.5, 10, 11 A universal marker appearing illusory to obtain, a combination of biomarkers seems the best way to explore GSCs for potential routine identification.