LCN2 deficiency has also been found to reduce BBB disruption and neuroinflammation and oxidative stress at 24 hours after ICH, thrombin induced hydrocephalus and SAH.8, 21, 22 The exact mechanisms by which LCN2 is involved in BBB disruption, oligodendrocyte injury, and myelin damage are still unclear. The gene discussed is LCN2; the disease is Hydrocephalus.