Brain edema and BBB disruption are important components of early brain injury, and brain edema is a risk factor for worse outcome after brain hemorrhage.18, 19 In addition, white matter injury leads cognitive dysfunction, depression, and motor deficits.20 Our previous studies showed that T2‐hyperintensity lesions coincided with albumin leakage.8, 12 However, those studies did not examine animals without T2 hyperintensities because almost all mice had extended T2‐hyperintensity lesions in white matter at 24 hours. Here, ALB is linked to depressive disorder.