EGF and cancer: Metastasis of EOC is intricately related to its tumor microenvironment.30 The EGF/EGFR signaling pathway is known to play an important role in modulating the tumor microenvironment, and upregulation of the EGFR signaling pathway is associated with uncontrolled cell division and poor prognosis for multiple cancer types.31, 32 In the case of ovarian cancer, overexpression of EGFR has been linked with tumor growth and metastasis.9 However, the specific mechanism by which the EGFR pathway regulates the tumorigenesis of EOC remains poorly understood.