There has been some speculation that proinflammatory cytokines produced by DENV‐specific T cells contribute to clinical disease severity by leading to endothelial dysfunction.20, 35, 36 Highly cross‐reactive, DENV‐specific CD8+ T‐cell clones, which produced cytokines such as TNF‐α, were thought to contribute to vascular leak. This evidence concerns the gene CD8A and endothelial dysfunction.