CD8A and dengue disease: While many studies have been carried out to elucidate the functionality of T‐cell responses in dengue, these have been limited to studying T‐cell specific for particular HLA types by using tetramers/pentamers.10, 20 As the functionality of DENV‐specific T cells in acute dengue have not been assessed previously in relation to clinical disease severity and resolution of viraemia, we sought to determine whether polyfunctional CD8+ T‐cell responses to DENV were associated with milder disease and early resolution of viraemia.