Meanwhile, compared with the diabetes + hUSCs‐Exo control group, the expression of VEGFA, MCP‐1, TGF‐β1 and TNF‐α was reduced in the diabetes + hUSCs‐Exo miR‐16‐5p group (all P < .05), while elevated levels were detected in the diabetes group (all P < .05). This evidence concerns the gene TGFB1 and diabetes mellitus.