As a new class of transcription regulators, miRNAs have been shown to play important roles in hyperglycaemia‐induced podocyte dysfunction.25 Reports have previously demonstrated that the overexpression of miR‐29a ameliorates podocyte dysfunction induced by hyperglycaemia through the promotion of nephrin acetylation, highlighting its protective effect on diabetic podocytopathy.26 The in vitro and in vivo experiments results revealed that secretion of miR‐16‐5p from hUSC exosomes could ameliorate podocyte injury induced by HG. Here, NPHS1 is linked to Hyperglycemia.