INS and Cognitive impairment: The study proved that developing IR was closely associated with increased autophagy.20 Studies have provided evidence that autophagy is induced in fat, liver, and high‐fat diet‐fed mice,21 and autophagy is also induced in the peripheral insulin‐sensitive tissues in response to the IR.22 And inhibition of autophagy showed the potential protection of cognitive impairment and spatial learning, which was partly mediated by CREB activation.23 The major pathophysiological feature in neurodegenerative diseases is synaptic dysfunction.