There is evidence that Ki67 is involved in cell division,7 and its immunohistochemical (IHC) detection is used to evaluate tumour proliferation.8 The p53 protein is involved in cancer development.9 Several studies in mice have shown that p53 mutations can result in a more aggressive tumour behaviour and metastasis.10, 11 E‐cadherin mediates cell‐cell adhesion and is expressed by epithelial cells.12 Damage in E‐cadherin structure or alteration in its expression are related to tumour progression and metastasis.13 This evidence concerns the gene TP53 and neoplasm.