Several parameters have been investigated as prognostic predictors of BC, such as lymph node status, tumour size, histologic type, tumour grade, hormonal receptor status, ploidy and proliferating markers.43, 44 Some authors have suggested a key role of E‐cadherin in tumour development and growth within the lymph nodes.45 Matrix‐degrading enzymes have been related to BC progression,46 tumour vascularization, invasion and metastasis, differentiation, proliferation and apoptosis,47 and hence MMPs are now considered to be multifaceted during cancer progression. The gene discussed is NR4A1; the disease is neoplasm.