Metastasis is the main cause of death in patients with cancer, and it has been estimated that approximately 90% of BC deaths arise from the metastatic spread of primary tumours.33 For this reason, the main objective of this work was to study the effects of RT on MMP and TIMP expression, as well as their relationship with other variables related to patient and tumour characteristics, and examine their role as prognostic and predictive factors in BC in relation to their key role in tumour invasion and metastasis. Here, TIMP1 is linked to breast cancer.