TRPM2 and Alzheimer disease: Amyloid‐β peptide‐induced ROS generation‐mediated activation of the TRPM2 channel results in synaptic loss and neuronal death in hippocampus,38, 41, 55 microglial cell activation and generation of proinflammatory mediators37, 55, 56 and impairments in the BBB and neurovascular function,35 supporting a critical role of the TRPM2 channel in the pathogenesis of AD.57