EPHX1 and Miyoshi myopathy: We found that Rub1024 or PR671A was (after treatment for 24 hours) not toxic in JJN3 or RPMI 8226 cells (Figure S2A,B), while Rub999 induced significant cell death in both MM cell lines but at higher concentrations as compared to BTZ or EPOX (IC50 = 150 nM for JJN3 and 180 nM for RPMI 8226; Figure S2A1,B1); a comparative summary of cell viability after exposing JJN3 and RPMI 8226 cells to different doses of the studied PIs is shown in Figure S3.