Interestingly, several years ago, Chen et al. disclosed that DKK1 promotes HCC cell migration and invasion and that it exerted its pro invasive function by stimulating beta catenin expression and transcription, although our results suggested that DKK1 downregulates beta catenin expression in PLC/PRF/5 and still induces invasion and migration in this cell line. This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.