GSTM1 and obesity due to melanocortin 4 receptor deficiency: While most research results confirm that surgery [13,19,21,27–30,32,43–46] and radiotherapy [22,27,29,32] history are not related to PE, other clinical features, such as obesity [22,27], anaemia (Hb < 100 g/L) [9,21,31,47], DVT [26], and hospitalization in the 12 months before the diagnosis of LC [48], may be associated with PE in LC patients.