To determine if regulation of tumor cell survival by CRT is specific to melanoma or represents a more wide-spread phenomena in cancer, we obtained cells established from multiple solid tumor types, including breast (MDA-MB361), kidney (RCC4), colon (HCT116), ovarian (SKOV1), and neuronal (H80) tumors, and analyzed the effects of CRT knockdown on their viability. This evidence concerns the gene CALR and melanoma.