TTR and Familial transthyretin-related amyloidosis: There are many types of amyloidosis based on the affected protein, but more than 90% of the cardiac involvement is represented by light chain amyloidosis (AL) and transthyretin amyloidosis (ATTR).[1] ATTR has 2 sub-types: an acquired “wild-type” form ATTR (ATTRwt) and a genetically transmitted form – mutant ATTR (ATTRm).[1,4] The treatment and the prognosis of disease depend on the localization and the type of amyloid disease.