BCL2L11 and lymphoproliferative syndrome: BIM, also called Bcl-2-like protein 11, is a protein that in humans is encoded by the BCL2L11 gene.[20] BIM functions in a variety of physiology and pathology events, starvation or drug could induce dual role of BIM in apoptosis and autophage, BIM is involved in autoimmune diseases, neurogenerative disorders, diabetes, fibrosis, cancer, and myelo/lymphoproliferative disorders.[21] Up to now, there are several kinds of compounds designed based on BIM-BH3 domain to be anti-cancer agent.