THPO and chronic liver failure: Patients with ESLD generally manifest impaired synthesis of clotting factors, excessive fibrinolysis, disseminated intravascular coagulation, thrombocytopenia due to impaired synthesis of thrombopoietin and immune destruction, and platelet dysfunction owing to circulating platelet inhibitors and deficiency of platelet glycoprotein receptors.[1] The anhepatic phase during LT can induce more coagulopathy.