Fabry disease (FD, OMIM # 301500), is an X‐linked disease caused by variants in the GLA gene (GenBank reference sequence NG_007119.1), located at locus Xq22.1, producing deficient hydrolysis activity of α‐galactosidase A enzyme (α‐Gal A; E.C. 3.2.1.22), which leads to progressive lysosomal accumulation of globotriaosylceramide (Gb3, ChemIDplus 0071965576) and globotriaosylsphingosine (lyso‐Gb3, ChemIDplus 0126550865) in cells and body tissues (Desnick, Ioannou, & Eng, 2001). This evidence concerns the gene GLA and Fabry disease.