No differences were observed between hemophilia patients and the reference group in ACAN VNTR (p > .10) and IL1RN*2 VNTR (p > .5) allele frequencies, as well as in the most common IL1RN*2 VNTR genotypes 4,4 and 4,2 (p = .32) or total genotypes of ACAN VNTR (p > .6). The gene discussed is ACAN; the disease is hemophilia.