Meta‐analysis established a significant association between Lys198Asn SNP of EDN1 gene and ischemic stroke when assuming either recessive model (OR: 1.30; 95% CI: 1.02–1.65; p = .03; I2 = 41%) or dominant model (OR: 1.48; 95% CI: 1.24–1.76; p < .001; I2 = 61%). Here, EDN1 is linked to ischemic stroke.