In multivariate analysis, tumor size (HR, 1.591; 95%CI, 1.250‐2.026; P<.001) and liver cirrhosis (HR, 1.381; 95% CI, 1.105‐1.726; P = .005) were independent predictive factors for TTR, while tumor size (HR, 2.206; 95% CI, 1.626‐2.994; P < .001) and AFP level (HR, 1.307; 95% CI, 1.018‐1.679; P = .036) were independent predictive factors for OS (Table S1). The gene discussed is TTR; the disease is neoplasm.