LAMB2 and neuromuscular disease caused by qualitative or quantitative defects of alpha-dystroglycan: To date, at least 18 genes have been implicated in dystroglycanopathies and their products elaborate sequentially the functional glycosylation of α‐dystroglycan (core M3 glycan) required for binding with (ECM) ligands, e.g., laminins, perlecan, and neurexin (Fig 1A) 4, 5.