And knockdown of CARD10 suppressed bladder tumour cell (UMUC3 and T24) proliferation and promoted apoptosis, thus we supposed CARD10 might act as an oncogene in bladder cancer.12, 18 CARD10 plays a critical role in intracellular signalling transduction and impacts many oncologic processes in tumour proliferation, metastasis, angiogenesis, and stemness and chemotherapeutic resistance.19, 20, 21 These characteristics may render it a therapeutic target. This evidence concerns the gene CARD10 and urinary bladder neoplasm.