FcγR IIb, which is the only Fcγ family receptor on the surface of B cell, is a negative regulator of innate immunity and acquired immunity.50, 51 The CD3‐CD19+CD32+ B cells in the CH group were significantly higher than those in the CA and N groups, suggesting that the immune system controlled the excessive activation and proliferation of B cells by the increased CD32+ B cells in the immune‐clearance period of chronic hepatitis B. In our study, FcγR Ia and FcγR Ib were differentially expressed between AH and CA1 phases as well as CA1 and CH1 phases. This evidence concerns the gene CD19 and chronic hepatitis B virus infection.