Acute hepatitis B; no history of hepatitis B; negative for the presence of five serological markers of hepatitis B for nearly 2 months; acute onset; HBV surface antigen (HBsAg) and hepatitis B core antibody (HBcAb) IgM positive; and symptoms such as jaundice and pain over the liver area, but no signs of chronic liver disease and cirrhosis, portal hypertension, hypersplenism, and ascites. The gene discussed is CD40LG; the disease is Cirrhosis.