Acute colitis is a common idiopathic disease characterized by intestinal epithelial barrier damage and inflammatory homoeostasis damage, leading to the secretion of pro‐inflammatory cytokines, such as TNF‐α, IFN‐γ, IL‐1β and IL‐6,27 associated with DSS‐induced colitis.28 Herein, we found that TOE relieved the severity of DSS‐induced colitis and inflammatory infiltration and decreased the production of cytokines TNF‐α, IL‐1β and IL‐6, suggesting that TOE might exhibit an anti‐inflammatory activity in DSS‐induced colitis. This evidence concerns the gene TNF and colitis.