CCL20 can be induced by inflammation in endothelial cells, monocytes and dendritic cells,37 and CCL20 and its receptor CCR6 are associated with inflammatory bowel disease (IBD).38, 39 CXC chemokines CXCL1/5 can be produced by colon epithelial cells 40, 41 and participate in inflammatory response by recruiting neutrophil in colitis.42 Herein, TOE had the protective effects on DSS‐induced colitis by repressing the production of cytokines CCL20, CXCL1/5 and CCR6. This evidence concerns the gene CCR6 and colitis.