Aldh3a2 can code fatty aldehyde dehydrogenase in mammal,34, 35 and pathogenic variants of Aldh3a2 lead to Sjögren‐Larsson syndrome.36 Herein, we confirmed that TOE exhibited a promoting effect on the fatty acid degradation by increasing Acox3, Adh5 and Aldh3a2 expression in DSS‐induced colitis. The gene discussed is ACOX3; the disease is colitis.