The Goto‐Kakizaki (GK) rat is a T2DM rodent model that displays defective β‐cell mass, mild fasting hyperglycaemia and insulin resistance, and impaired glucose‐mediated insulin secretion; thus, diabetes mellitus in these rats is similar to T2DM in humans.16, 17 Herein, we hypothesized that kirenol may protect against DCM by attenuating cardiac remodelling via inhibition of both inflammatory and fibrotic signalling pathways. This evidence concerns the gene INS and familial dilated cardiomyopathy.