Some of the CCA‐related lncRNAs were excavated to play vital roles during the genesis and development of CCA recent years, for instance lncRNA TUG1 suppression inhibits CCA metastasis potential by reversing EMT, SNHG1 binds to the histone methyltransferase enhancer of EZH2 and PRC2 to alter the CCA migration as well as proliferation in vitro and in vivo, AFAP1‐AS1 promotes the CCA proliferation and metastasis while providing potential therapeutic target for CCA.29, 30, 31, 32. This evidence concerns the gene EZH2 and cholangiocarcinoma.