Due to the importance of oxidative stress in diabetes and insulin resistance, and the application of RSV in attenuating oxidative stress, we investigated the effects of different doses of RSV (1, 5 and 10 mg/kg.bw) on blood glucose, insulin level and insulin resistance, oxidative stress marker (SOD) in the sera of T2DM rats. Here, SOD1 is linked to type 2 diabetes mellitus.