VCAM1 and colorectal cancer: It is now known that VCAM‐1 is involved in mediating tumor cell adhesion to vascular endothelial cells and promoting the metastatic process.17 Also, serum concentrations of ICAM‐1 and VCAM‐1 are significantly elevated in the patients with colorectal cancer in comparison with a group of healthy subjects.18 One of the possible mechanisms is that the rolling cancer cells become activated by locally released chemokines present at the surface of endothelial cells.