High fat diet feeding and obesity were demonstrated to cause global DNA hypomethylation in the placenta of mice, with additional differential methylation of placental Igf2r regions that serve as binding sites for important transcription factors, including Pax4, Smarca3, Vbp, Pax6, Yy1, Oct1, Nrf2/Arp, Ppar/Rxr, Egr3, Rxr, Mzf1, Sry/Sox9, Gcm1, Stat6, Nudr/Deaf‐1. The gene discussed is DEAF1; the disease is Obesity.