Differential methylation of 23 449 genes (HLA‐DQA1, HLA‐DQB1, and TSPAN18 were most significant), and changes in expression of 3074 genes, involved with insulin receptor signaling, type 2 diabetes signaling, and leptin signaling in obesity in offsprings born after weight loss. This evidence concerns the gene HLA-DQB1 and obesity due to melanocortin 4 receptor deficiency.