Iron deficiency suppressed hippocampal expressions hypoxia‐inducible factor 1, dual‐specificity phosphatase 4, IGF 2, and myelin basic protein, and Bndf‐IV P4 methylation, H4 acetylation, K4me3, and binding of RNA polymerase II and USF‐1. It increased HDAC1 binding to Bndf‐IV promoter, and K27me3 and K4me1. The gene discussed is HDAC1; the disease is Iron deficiency anemia.