Hypercholesterolemia, hyper‐triacylglycerolemia, hyperglycemia, glucose intolerance, hyperinsulinemia and insulin resistance, increased leptin and resistin, increased adiposity, and leptin resistance characterized by altered expression of neuropeptide Y and proopiomelanocortin (POMC) in F1 and F2 offsprings. The gene discussed is LEP; the disease is familial hypercholesterolemia.