Laker et al. demonstrated that maternal high fat diet feeding induced hypermethylation of the muscle peroxisome proliferator‐activated receptor γ coactivator‐1α (Pgc‐1α) in rat, with consequent decreases in the expression of Pgc‐1α and its target genes (Glut4, Cox4, and Cyt c) leading to the development of insulin resistance in offsprings exposed prenatally to high fat diet.172 Decreased H3K9Ac and increased H3K9me2 in the white adipose tissue adiponectin promoter, and increased H4K20me in the leptin promoter have also been reported in mice exposed prenatally to high fat diet. The gene discussed is PPARGC1A; the disease is Insulin resistance.