Altered testes mRNA (414 genes involved in nitric oxide and ROS pathways, Sertoli cell junction signaling, EIF2 signaling, NF‐κβ signaling and inflammatory response, lipid metabolism, and carbohydrate metabolism), and sperm and testes microRNA (11 microRNAs mostly involved in metabolic disease, cell death, production of ROS, DNA replication, NF‐κB signaling, p53 signaling, recombination and repair, lipid metabolism, spermatogenesis, and embryonic development) expression. The gene discussed is EIF2S1; the disease is metabolic disease.