The alleles and genotypes of DNMT3B-579G>T did not have different risks of MS development under various models (OR Tvs. G = 0.95, 95% CI = 0.67-1.35, P = 0.86; OR GT vs. GG = 0.80, 95% CI = 0.46-1.38, P = 0.48; OR TT vs. GG = 0.97, 95% CI = 0.48-1.96, P > 0.99; OR GT+TT vs. GG = 0.84, 95% CI = 0.50-1.41, P = 0.60; and OR GG+GT vs. TT = 1.11, 95% CI = 0.59-2.07, P = 0.87, respectively). Here, DNMT3B is linked to myeloid sarcoma.