Strategy of vascular system is quite complicated.7 Furthermore, vascular endothelial growth factor (VEGF) family is capable to organize tumor vascularization and is, basically, originated through the evolution in non-vertebral species.8 Epidermal growth factor (EGF) has the key role in differentiation, cell proliferation, tumorigenesis, and apoptosis. The gene discussed is EGF; the disease is neoplasm.