In rodents, the consumption of a diet enriched in n − 3 PUFAs prevents the dysregulation of cytokine production in hippocampal microglial cells in response to Lipopolysaccharide (LPS) [124], reduces hippocampal Aβ plaque density by modifying the fibrillar/prefibrillar Aβ oligomer ratio (the former are less toxic), and leads to mild improvements in the behavioral testing of the transgenic APP/PS1 rodent model of AD [125]. Here, APP is linked to Alzheimer disease.