This association is based on the close correlation of bladder cancer incidence with the prevalence of S. haematobium infection within different geographic areas [16–20], as well as expression of markers such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in urinary schistosomiasis patients [21]. Here, NOS2 is linked to urinary schistosomiasis.